Pharmacology

  • Drug Delivery Development SpecialistsExpert knowledge of the toxicity of the major chemical and biological threat agents with a focus on organophosporus nerve agents, their mechanism of action, and the known treatment and antidotes for these poisons
  • Expert knowledge of drugs associated with cholinergic and adrenergic autonomic receptors, anesthesia, CNS receptors, cardiovascular and respiratory systems as well as the gastrointestinal tract

MSA principals have designed, implemented and evaluated studies including:

  • Clinical studies utilizing CNS drugs to correlate the dose administered, with blood levels and renal metabolites
  • Drug, drug interaction (DDI) studies with auto-injector delivery
  • In vivo and in vitro evaluation of potential antidotes and prophylactic drugs for organophosphate nerve agents including sarin, soman, tabun and VX
  • The use of Butyrylcholinesterase as a scavenger for enzyme susceptible drugs such as organophosphates and cocaine
  • The development and use of antibodies to induce systemic immunity to organophosporus compounds
  • An immunologic approach to the identification and development of vaccines to various toxins
  • Principal Investigator on a DTRA project for the development of a rapid detection system for biologic threat agents based upon DNA analysis. Developed DNA based probes for anthrax, plague and dengue fever
  • Characterization of the ricin toxin